Anti-inflammatory Activity Assessment
Certain functional food ingredients are claimed to have anti-inflammatory effects, the validation of which involves testing the ability of the ingredients to reduce the inflammatory response and their effects on inflammatory markers. Aprofood provides you with scientific validation services before your products are marketed and promoted for their anti-inflammatory properties.
Fig 1. Proinflammatory and anti-inflammatory diets around the world. (Stromsnes K, et al., 2021)
Common Anti-inflammatory Ingredients
A wide range of plant and marine-sourced food ingredients are rich in a variety of bioactive ingredients with anti-inflammatory properties, common examples are as follows.
- Curcumin. Curcumin is a natural compound found in turmeric and has potent anti-inflammatory properties. It inhibits various inflammatory pathways and mediators, including NF-kB and COX-2, thus reducing inflammation in the body.
- Resveratrol. Resveratrol is a polyphenol in grapes, red wine, and certain berries. It has anti-inflammatory effects by modulating various inflammatory signaling pathways and reducing the production of inflammatory cytokines.
- Omega-3 fatty acids. In fatty fish and fish oil supplements, omega-3 fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) possess anti-inflammatory properties. They can reduce the production of pro-inflammatory molecules and promote the synthesis of anti-inflammatory molecules.
- Quercetin. Quercetin is a flavonoid found in various fruits, vegetables, and herbs. It acts as an antioxidant and exhibits anti-inflammatory effects by inhibiting inflammatory enzymes and reducing the production of inflammatory cytokines.
- Gingerol. Gingerol is a bioactive compound found in fresh ginger. It has anti-inflammatory effects by inhibiting COX-2 and reducing the expression of pro-inflammatory cytokines.
Our Service
Utilizing advanced molecular analytical techniques, in-depth cellular studies, animal model experiments, and bioinformatics tools, Aprofood helps evaluate the anti-inflammatory activity of various ingredients and investigate the underlying mechanisms, revealing the complex relationship between functional compounds and inflammatory responses.
Service Process of Anti-inflammatory Activity Assessment
Anti-inflammatory Activity Assessment
01 Assessment & Planning
Target Confirmation. Understand the specific aspects that you want to investigate.
Experimental Design. Based on the properties of the ingredient and your desired objectives, we will provide a well-designed experiment, including both in vivo and in vitro assays.
04 Verification Report
Data Analysis. Analyze the collected data using appropriate statistical methods to determine the anti-inflammatory activity of the subject ingredients.
Report Generation. Provide a comprehensive report, including study design, methods and conclusions, summarizing the anti-inflammatory effects of the functional ingredient.
02 In Vitro Testing
Cell Culture Studies. Use cell-based modeling studies to assess the anti-inflammatory potential of components. For example, macrophages or other immune cultured cells are exposed to an inflammatory stimulus, and the effect of the functional component on inflammatory mediators is measured. Commonly measured parameters include cytokine levels (IL-6, TNF-alpha, etc.), NF-kB activity, and COX-2 expression.
03 In Vivo Testing
Animal Model Selection. Select animal models that mimic human inflammatory conditions.
Treatment Design. Determine dosages and duration of administration based on human equivalent doses and toxicity studies.
Biomarker & Histological Analysis. Collect blood and tissue samples to measure inflammatory biomarkers, cytokines, and other relevant indicators. Conduct histological analysis to assess the ingredient's impact on inflammatory cell infiltration and tissue damage.
Applications of Our Service
Our services can be applied to various food-related areas, including but not limited to the following.
- Health Diet Solutions Research
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Dietary Supplements Development
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Nutraceuticals Development
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Food and Beverage Development
What Sets us Apart?
Advanced Analytical Tools
Using state-of-the-art analytical tools for pragmatic and precise evaluation of anti-inflammatory properties of nutritional components.
Experienced Scientists
A team of seasoned researchers versed in the field of bio-sciences to guarantee accurate results and insightful conclusions.
Cutting-edge Lab Facilities
Equipped with modern, high-grade lab facilities that ensure reliability and efficiency in research procedures.
Evidence-based Approach
Adopting a science-backed and data-driven methodology that underscores the credibility of the findings.
As an expert in the food industry, Aprofood specializes in functional food ingredient supply and contract development of new ingredients. Our technical capabilities include state-of-the-art analytical tools, multi-omics research methodologies, and research protocols tailored to individualized differences, allowing us to provide useful insights into product development for food organizations or companies. Please feel free to contact us.
Reference:
- Stromsnes, K.; et al. Anti-Inflammatory Properties of Diet: Role in Healthy Aging. Biomedicines. 2021; 9(8):922.
For Research Use Only.
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