Natamycin
Cat. Number: FA-00391
Size: 1g, 5g, 10g, Custom size
Description
Natamycin is a polyene antibiotic that generally finds application as an antifungal agent as it lacks development of resistance and has a broad spectrum of activity. However, its mode of action is yet unclear, direct binding and isothermal titration calorimetry studies has revealed that natamycin binds specifically to ergosterol present in model membranes.
Natamycin shows activity against both molds and yeasts. It finds applications as a fungicidal and antibiotic preservative in the food industry.
Product Details
CAS Number
7681-93-8
Source
Streptomyces natalensis
Linear Formula
C33H47NO13
Application
Cleaning products; cosmetics; food and beverages; personal care
Appearance
powder
Molecular Weight
665.73
Storage Temp.
2-8 °C
Antibiotic Activity Spectrum
fungi
SMILES
C[C@@H]1C\C=C\C=C\C=C\C=C\[C@@H] (C[C@@H]2O[C@] (O) (C[C@@H] (O)C[C@H]3O[C@@H]3\C=C\C (=O)O1)C[C@H] (O)[C@H]2C (O)=O)O[C@@H]4O[C@H] (C)[C@@H] (O)[C@H] (N)[C@@H]4O
InChI
1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21 (45-32-30 (39)28 (34)29 (38)19 (2)44-32)15-25-27 (31 (40)41)22 (36)17-33 (42,47-25)16-20 (35)14-24-23 (46-24)12-13-26 (37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3, (H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
InChI key
NCXMLFZGDNKEPB-FFPOYIOWSA-N
Handling Precaution
An antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. However, unlike nysatin and filipin, pimaricin does not change the permeability of the plasma membrane.
For Research Use Only!
