Spermine
Cat. Number: FPH-00354
Size: 1 g, 5 g, 10g, Custom size
Description
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Product Details
CAS Number
71-44-3
EC Number
200-754-2
Synonyms
N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine
Source
Microbial, Synthetic
Linear Formula
NH2(CH2)3NH(CH2)4NH(CH2)3NH2
Application
Spermine has been used: in the buffer, to swap the divalent cations in the MgSO4 protocol to stabilize the integrity of the chromosomes; in the preparation of modified mica surfaces from freshly cleaved mica surfaces; to study its effects on survival in mice with sepsis and to estimate the role of spermine in lethal systemic inflammatory diseases.
Available Grade
BioReagent
Appearance
Solid
Assay
≥96%
Molecular Weight
202.34
Storage
2-8 °C
SMILES
[H]N(CCCN)CCCCN([H])CCCN
InChI
1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChI key
PFNFFQXMRSDOHW-UHFFFAOYSA-N
Handling Precaution
Spermine together with putrescine and spermidine compose a family of polyamines (polycations) that are required for the growth and survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycans, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols.
For Research Use Only!
